p21 as a transcriptional co-repressor of S-phase and mitotic control genes.
It has been previously described that p21 functions not only as a CDK inhibitor but also as a transcriptional co-repressor in some systems.To investigate the roles of p21 in transcriptional control, we studied the gene expression changes in two human cell systems.Using a human leukemia cell line (K562) with inducible p21 expression and human primar